GSK, CureVac’s next-gen COVID-19 vaccine reveals promise in monkey trial Reuters by way of


© Reuters. FILE PHOTO: A lady holds a small bottle labelled with a “Coronavirus COVID-19 Vaccine” sticker on this illustration taken, October 30, 2020. REUTERS/Dado Ruvic/File Photograph


By Ludwig Burger and Yadarisa Shabong

(Reuters) -GlaxoSmithKline and CureVac mentioned a examine on macaque monkeys confirmed their jointly-developed mRNA COVID-19 vaccine candidate to be “strongly improved” in defending in opposition to the virus in contrast with CureVac’s first try.

The encouraging information on its “second-generation” vaccine gave CureVac’s German-listed shares an 8% elevate, because the inventory regularly recovers from a stoop in June when the German biotech firm’s first vaccine candidate recorded a disappointing 48% efficacy in mass testing on people.

The businesses mentioned on Monday {that a} blood evaluation of the animals confirmed that the next-generation vaccine generally known as CV2CoV triggered virus-fighting antibodies in addition to immune cells that concentrate on contaminated cells sooner and in larger portions than CureVac’s first-generation vaccine candidate.

The surge in antibodies and immune cells was much like that noticed after an actual an infection with SARS-CoV-2, the coronavirus that causes COVID-19, they mentioned.

Greater antibody blood counts have been noticed throughout virus variants of concern, together with the Beta, Delta and Lambda lineages, they added.

When contaminated with the unique SARS-CoV-2 virus detected within the Chinese language metropolis of Wuhan, macaques vaccinated with CV2CoV had higher clearance of the virus within the lungs and nasal passages, when evaluating the 2 vaccines.

The outcomes have but to be peer-reviewed for publication in a medical journal.

U.S.-listed shares of CureVac, which additionally reported its quarterly monetary outcomes on Monday, have been up 9.5% in pre-market buying and selling.

GSK and CureVac teamed up in February in a 150 million euro ($177 million) deal to develop the next-generation COVID-19 vaccine from subsequent 12 months, in an try to sort out a number of variants with one shot.

Preliminary testing of CV2CoV on people would start over the past quarter of this 12 months, CureVac mentioned.

($1 = 0.8496 euros)